SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Van De Bunt Martijn)
 

Search: WFRF:(Van De Bunt Martijn) > Scott Robert A > Integrative genomic...

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Lotta, Luca A. (author)
University of Cambridge
Gulati, Pawan (author)
University of Cambridge
Day, Felix R (author)
University of Cambridge
show more...
Payne, Felicity (author)
Wellcome Trust Sanger Institute
Ongen, Halit (author)
van de Bunt, Martijn (author)
University of Oxford
Gaulton, Kyle J (author)
Eicher, John D. (author)
National Heart Lung and Blood Institute
Sharp, Stephen J. (author)
University of Cambridge
Luan, Jian'an (author)
University of Cambridge
De Lucia Rolfe, Emanuella (author)
University of Cambridge
Stewart, Isobel D. (author)
University of Cambridge
Wheeler, Eleanor (author)
Wellcome Trust Sanger Institute
Willems, Sara M (author)
University of Cambridge
Adams, Claire (author)
University of Cambridge
Yaghootkar, Hanieh (author)
University of Exeter
Sharp, Stephen J. (author)
University of Cambridge
Forouhi, Nita G. (author)
University of Cambridge
Kerrison, Nicola D. (author)
University of Cambridge
Sims, Matt (author)
University of Cambridge
Lucarelli, Debora M E (author)
University of Cambridge
Deloukas, Panos (author)
University of Cambridge
McCarthy, Mark I. (author)
University of Oxford
Arriola, Larraitz (author)
Balkau, Beverley (author)
Centre for Research in Epidemiology and Population Health (CESP)
Barricarte, Aurelio (author)
Boeing, Heiner (author)
German Institute of Human Nutrition
Franks, Paul W. (author)
Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Gonzalez, Carlos (author)
Grioni, Sara (author)
Kaaks, Rudolf (author)
German Cancer Research Centre
Key, Timothy J (author)
University of Oxford
Navarro, Carmen (author)
Murcia Regional Health Council
Nilsson, Peter M. (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
Overvad, Kim (author)
Aalborg University Hospital,Aarhus University
Palli, Domenico (author)
Cancer Research and Prevention Institute (ISPO)
Panico, Salvatore (author)
University of Naples Federico II
Quirós, J Ramón (author)
Public Health Directorate
Rolandsson, olov (author)
Umeå universitet,Umeå University,Allmänmedicin
Sacerdote, Carlotta (author)
Salamanca-Fernández, Elena (author)
Slimani, Nadia (author)
Tjonneland, Anne (author)
Danish Cancer Society
Tumino, Rosario (author)
Spijkerman, Annemieke M. W. (author)
van der A, Daphne L. (author)
van der Schouw, Yvonne T. (author)
Riboli, Elio (author)
Imperial College London
Semple, Robert K (author)
University of Cambridge
Stears, Anna (author)
Addenbrooke's Hospital
Khaw, Kay-Tee (author)
Johnson, Andrew D. (author)
Frayling, Timothy (author)
Dermitzakis, Emmanouil (author)
Barroso, Inês (author)
Wareham, Nicholas J. (author)
Langenberg, Claudia (author)
O'Rahilly, Stephen (author)
Scott, Robert A. (author)
show less...
 (creator_code:org_t)
 
show more...
 
show less...
2016-11-14
2017
English 10 s.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:1, s. 17-26
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with insulin resistance phenotypes (higher fasting insulin levels adjusted for BMI, lower HDL cholesterol levels and higher triglyceride levels) and provide evidence that their link with higher cardiometabolic risk is underpinned by an association with lower adipose mass in peripheral compartments. Using these 53 loci, we show a polygenic contribution to familial partial lipodystrophy type 1, a severe form of insulin resistance, and highlight shared molecular mechanisms in common/mild and rare/severe insulin resistance. Population-level genetic analyses combined with experiments in cellular models implicate CCDC92, DNAH10 and L3MBTL3 as previously unrecognized molecules influencing adipocyte differentiation. Our findings support the notion that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view